| Symptom Cluster | Recommended Classes | Classes to Avoid | First-line Antidepressants |
|---|---|---|---|
| Insomnia | NaSSA | NDRI | Mirtazapine |
| Hyperarousal | SARI | SNRI | Nefazodone |
| Weight loss | Sedating SSRI | Paroxetine | |
| Trazodone |
NaSSA, noradrenergic specific serotonergic antidepressant; NDRI, norepinephrine dopamine reuptake inhibitor; SARI, serotonin antagonist reuptake inhibitor; SNRI, serotonin norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor.