| Symptom Cluster | Recommended Classes | Classes to Avoid | First-line Antidepressants |
|---|---|---|---|
| Chronic pain | TCA | None | Amitriptyline |
| Headache | SNRI | Duloxetine | |
| Somatization | Milnacipran | ||
| Nortriptyline |
SNRI, serotonin norepinephrine reuptake inhibitor; TCA, tricyclic antidepressant.