Table 3. Recommended Treatment for Depression with Fatigue

Symptom Cluster	Recommended Classes	Classes to Avoid	First-line Antidepressants
Fatigue	NDRI	NaSSA	Bupropion
Anhedonia	SNRI	SARI	Desvenlafaxine
Weight gain	Activating SSRI		Fluoxetine
			Venlafaxine

NaSSA, noradrenergic specific serotonergic antidepressant; NDRI, norepinephrine dopamine reuptake inhibitor; SARI, serotonin antagonist reuptake inhibitor; SNRI, serotonin norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor.