| Outcomes | FDC(n = 795) | FEC(n = 712) | Monotherapy(n = 7169) | P Values* | ||
|---|---|---|---|---|---|---|
| FDC vs FEC | FDC vs Mono | FEC vs Mono | ||||
| Systolic BP (mm Hg) | ||||||
| At index | 153.8 (16.5) | 147.8 (16.4) | 148.2 (14.7) | <.001 | <.001 | .47 |
| At follow-up | 132.3 (16.1) | 137.5 (18.6) | 134.9 (16.1) | <.001 | <.001 | <.001 |
| Unadjusted change | −21.5 (20.5) | −10.3 (20.7) | −13.3 (17.9) | <.001 | <.001 | <.001 |
| Risk-adjusted change | −17.3 (11.6) | −12.0 (11.5) | −13.6 (10.2) | <.001 | <.001 | .04 |
| Diastolic BP (mm Hg) | ||||||
| At index | 94.3 (11.1) | 85.9 (12.2) | 90.4 (10.6) | <.001 | <.001 | <.001 |
| At follow-up | 82.0 (10.6) | 79.8 (11.7) | 82.8 (10.5) | <.001 | .06 | <.001 |
| Unadjusted change | −12.3 (12.3) | −6.1 (12.5) | −7.6 (11.4) | <.001 | <.001 | .003 |
| Risk-adjusted change | −10.1 (6.8) | −6.0 (7.5) | −7.9 (6.6) | <.001 | <.001 | .34 |
| Goal attainment, n (%) | ||||||
| Unadjusted at goal | 440 (55.4) | 226 (37.4) | 3267 (45.6) | <.001 | <.001 | <.001 |
| Risk-adjusted at goal | 455 (57.2) | 303 (42.5) | 3216 (44.9) | <.001 | <.001 | .69 |
Data are mean (standard deviation) unless otherwise indicated.
↵* Unadjusted P values were calculated using analysis of variance or logistic regression, whereas risk-adjusted P values were from analysis of covariance or logistic regression.
FDC, fixed-dose combination; FEC, free-equivalent combination.