| Outcomes | ACEI (n = 3131) | Thiazide (n = 1947) | Cardioselective β-blocker (n = 1029) | ARB (n = 533) | CCB (n = 529) |
|---|---|---|---|---|---|
| Systolic BP (mm Hg) | |||||
| At index | 147.6 (15.0) | 149.3 (13.4) | 147.7 (15.4) | 147.8 (14.9) | 149.5 (15.7) |
| At follow-up | 133.6 (16.2) | 136.6 (14.9) | 134.9 (16.9) | 135.1 (15.8) | 136.7 (17.1) |
| Unadjusted change | −14.0 (18.1) | −12.7 (17.1) | −12.8 (18.2) | −12.7 (17.7) | −12.8 (19.5) |
| Risk-adjusted change | −13.4 (10.3) | −14.1 (9.3)† | −13.4 (10.8) | −13.3 (10.4) | −14.0 (10.9)‡ |
| Diastolic BP (mm Hg) | |||||
| At index | 90.1 (10.7) | 91.5 (10.1) | 90.1 (10.9) | 89.7 (10.4) | 89.4 (11.4) |
| At follow-up | 81.8 (10.1) | 84.6 (10.5) | 82.8 (10.8) | 82.5 (10.5) | 82.0 (11.1) |
| Unadjusted change | −8.3 (11.4)† | −6.8 (11.3) | −7.4 (11.3) | −7.1 (11.3) | −7.3 (11.9) |
| Risk-adjusted change | −7.9 (6.6) | −8.2 (6.3)† | −7.7 (6.8) | −7.6 (6.4) | −7.5 (7.0) |
| Goal attainment, n (%) | |||||
| Unadjusted at goal | 1465 (46.8)§ | 826 (42.4) | 508 (49.4)‖ | 229 (43.0) | 239 (45.2) |
| Risk-adjusted at goal | 1495 (47.8)† | 776 (39.9) | 472 (45.9)¶ | 230 (43.1) | 234 (44.2) |
Data are mean (standard deviation) unless otherwise indicated.
↵* Unadjusted P values were from analysis of variance or logistic regression, whereas risk-adjusted P values were from analysis of covariance or logistic regression.
↵† ACEI vs thiazide, P < .001.
↵‡ ACEI vs CCB, P = .04.
↵§ ACEI vs thiazide, P = .02.
↵‖ β-blocker vs thiazide, P = .003.
↵¶ β-blocker vs thiazide, P = .01.
ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker; CCB, calcium channel blocker; thiazide, thiazide and thiazide-like diuretics.