| Measures of High Cardiometabolic Risk | Measurement Components | Description |
|---|---|---|
| Metabolic syndrome26 | • Systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥85 mmHg | This is the first eligibility criteria calculated for patients. To meet the definition, patients must have 3 of the 5 risk factors. Although not associated with a specific risk percentage in a 10-year period, metabolic syndrome significantly increases the risk of CVD and diabetes. |
| • Waist circumference ≥40 inches (men) or ≥35 inches (women); if waist circumference is unavailable, BMI ≥30 kg/m2 | ||
| • HDL cholesterol <40 mg/dL (men) or <50 mg/dL (women) | ||
| • Triglycerides ≥150 mg/dL | ||
| • Fasting blood glucose ≥100 mg/dL | ||
| Reynolds CHD risk score24,25 | • Age | This score uses the most information, including C-reactive protein and family history of heart disease, in addition to risk factors in the Framingham risk score. |
| • Sex | ||
| • Tobacco use | ||
| • Systolic blood pressure | ||
| • Total cholesterol | ||
| • HDL cholesterol | ||
| • High-sensitivity C-reactive protein | ||
| • Family history of heart disease | ||
| Framingham CHD risk score23 | • Age | This score is assessed if there is no metabolic syndrome and incomplete information to assess the Reynolds risk score. |
| • Sex | ||
| • Tobacco use | ||
| • Systolic blood pressure | ||
| • Total cholesterol | ||
| • HDL cholesterol |
BMI, body mass index; CHD, coronary heart disease; CVD, cardiovascular disease; HDL, high-density lipoprotein.