Population | Treatment (Route of Administration Cited Only Where Provided) | Effectiveness |
---|---|---|
Patients with advanced cancer, referred for palliative care | Nabilone at 1 mg at bedtime or twice a day | 4/4 patients' night sweats improved (mean 5.75 points on the ESAS)134 |
Patients with terminal cancer | Thalidomide at 100 mg at bedtime | 6 /7 patients improved an average of 4 points on a 5-point scale; recurred off of drug and improved again with reinstitution of drug135 |
Patients with advanced local or metastatic cancer | Thioridazine at 10–30 mg at bedtime nightly | 15/17 patients reported improvement, poorly quantified136 |
Patients with myelofibrosis | Etanercept at 25 mg subcutaneously twice weekly for up to 24 weeks | 6/8 (75%) improved with treatment128 |
Patients treated for narcotic addiction with methadone | Desloratadine at 5 mg per day | 2/2 (100%) reported relief from night sweats within 1 day137 |
Patients taking SSRIs | Mirtazapine at 15–60 mg per day | One case: dose-dependent reduction in night sweats138 |
Patients taking SSRIs | Benztropine at 0.5 mg at bedtime | One case: temporary relief from night sweats84 |
Patients taking SSRIs | Terazosin at 1 mg per day to 2 mg at bedtime | Significant reduction in night sweats in 2/2 (100%), one after a day, the other after 4 weeks139 |
Patients taking SSRIs | Terazosin | Significant reduction in night sweats in 20/20 (100%)140 |
Patients taking SSRIs | Clonidine at 0.1 mg twice daily | One case: significant relief of night sweats after 3 week139 |
SSRIs, selective serotonin reuptake inhibitors; ESAS, Edmonton Symptom Assessment System (scored 0–10).