Table 1.

Blood Pressure Lowering in Large-scale Clinical Trials Comparing Newer with Older Antihypertensive Agents.

Clinical TrialTreatment GroupsMean Baseline BP (mm Hg)Mean BP Reduction (mm Hg)Persistence (% on Randomized Drug at End of Study)Tolerability (% Withdrawn Because of Adverse Effects)
CAPPP9,15Captopril (n = 5,492)161.8/99.811/8*Not reportedNot reported
Diuretics/β-blockers (n = 5,493)159.6 /98.1
STOP-210Felodipine/Isradipine (n =2,196)34.5 /17.5*66.2Not reported
Enalapril/Lisinopril (n = 2,205)194/98*34.5 /16.2*61.3Not reported
Diuretics/β-blockers (n = 2,213)34.8/16.6*62.3Not reported
INSIGHT11Nifedipine (n =3,157)173/99*35/17*69.023.0
Hydrochlorothiazide/amiloride(n = 3,164)72.016.4
NORDIL12Diltiazem (n = 5,410)173.5/105.820.3 /18.777.0Not reported
Diuretics/β-blockers (n = 5,471)173.4 /105.723.3/18.793.0Not reported
  • BP = blood pressure.

  • * No difference between groups (P > .05).

  • Difference between groups in systolic reduction (P < .001).