Relation Between Hormone Replacement Therapy Use and Perceived Risk, Quality of Life, and Selected Clinical Characteristics.
| Characteristic | RO* | 95% CI† | ROadj‡ | 95% CI |
|---|---|---|---|---|
| Race, white vs nonwhite | 1.6 | 0.7, 3.9 | 1.2 | 0.3, 4.7 |
| Smoking status, ever vs never | 1.9 | 1.1, 3.3 | 1.2 | 0.5, 2.9 |
| Exercise, 3/wk | 0.6 | 0.4, 1.0 | 0.6 | 0.3, 1.4 |
| Fractures, any history | 0.4 | 0.1, 0.9 | 0.5 | 0.1, 2.0 |
| Symptoms of menopause, any | 2.6 | 1.6, 4.5 | 6.3 | 2.3, 17.6 |
| Bone density treatment, any | 0.5 | 0.3, 1.0 | 0.7 | 0.2, 2.1 |
| Herbal medicine, any | 1.6 | 0.9, 2.9 | 1.9 | 0.8, 5.0 |
| Perceived risk difference | ||||
| High- vs low-risk difference§ | ||||
| Osteoporosis | 3.4 | 2.0, 5.9 | 4.7 | 2.1, 10.5 |
| Myocardial infarction | 3.3 | 1.9, 6.0 | 2.5 | 1.2, 5.3 |
| Uterine cancer | 0.5 | 0.3, 0.9 | 1.2 | 0.5, 2.8 |
| Breast cancer | 0.5 | 0.3, 0.9 | 0.5 | 0.2, 1.1 |
| Quality-of-life difference‖ | ||||
| High vs low QOL difference | ||||
| Osteoporosis | 2.0 | 1.2, 3.4 | 2.4 | 1.0, 6.0 |
| Myocardial infarction | 1.4 | 0.9, 2.3 | 1.7 | 0.7, 3.9 |
| Uterine cancer | 1.4 | 0.7, 2.6 | 1.7 | 0.5, 5.8 |
| Breast cancer | 2.8 | 1.6, 5.0 | 3.6 | 1.2, 10.7 |
* RO = relative odds, the odds of an HRT user having a characteristic divided by odds of an HRT nonuser having a characteristic.
† 95 percent confidence intervals.
‡ Relative odds adjusted by multivariate logistic regression, also including age (years).
§ Perceived risk difference = (lifetime probability on HRT) − (lifetime probability off HRT); the mean is used as the cutoff for the high and low group, except breast cancer for which the median is used.
‖ Quality of life (QOL) difference = QOL (current state of health) − QOL (with disease); the mean is used as the cutoff for the high and low group.