Possible Predictors of Response to Paroxetine (n = 152).
| Variable | Nonresponse | Response | Wald’s t (P Value) | ||
|---|---|---|---|---|---|
| No. | % | No. | % | ||
| Demographics | |||||
| Sex (female) | 28 | 44 | 45 | 51 | 0.01 |
| Older cohort ≥59 y | 47 | 75 | 48 | 54 | 5.40 (.02) |
| Ethnicity (majority) | 46 | 73 | 80 | 90 | 5.59 (.02) |
| Married | 30 | 48 | 48 | 54 | 0.39 |
| Employed | 16 | 25 | 42 | 47 | 2.37 |
| Income, y <$20,000 | 37 | 59 | 42 | 47 | 0.26 |
| Veteran | 22 | 35 | 19 | 21 | 1.49 |
| Dysthymia | 29 | 46 | 52 | 58 | 3.30 (.08) |
| Education ≤13 y | 32 | 51 | 40 | 45 | 0.36 |
| Site | df = 3; 5.81 (.12) | ||||
| Lebanon | 14 | 22 | 37 | 42 | |
| Pittsburgh | 7 | 11 | 11 | 12 | |
| San Antonio | 19 | 30 | 16 | 18 | |
| Seattle | 23 | 36 | 25 | 28 | |
| Mean | SD | Mean | SD | ||
| Patient beliefs (PAB) | |||||
| Biological belief | 3.6 | 0.9 | 3.0 | 1.0 | 11.74 (.001) |
| Psychological belief | 3.5 | 1.0 | 3.6 | 0.8 | 0.01 |
| Clinical | |||||
| Duke Severity of Illness | 25.3 | 14.6 | 19.6 | 13.2 | 1.51 |
| NEO—Neuroticism Scale | 3.0 | 0.7 | 3.1 | 0.6 | 0.01 |
| SCL scales | |||||
| Depression | 1.6 | 0.6 | 1.5 | 0.6 | 0.01 |
| Somatization | 1.3 | 0.6 | 0.9 | 0.7 | 2.46 (.12) |
| Anxiety | 0.9 | 0.6 | 0.8 | 0.6 | 7.34 (.007) |
| Hostility | 0.7 | 0.6 | 0.8 | 0.6 | 0.01, 2.68 (.10) |
| Interpersonal sensitivity | 1.1 | 0.7 | 1.0 | 0.7 | 4.32 (.04) |
| SF-36 scales | |||||
| General health | 43.4 | 21.4 | 58.5 | 22.2 | 12.04 (.001) |
| Physical function | 51.6 | 28.9 | 64.0 | 26.9 | 4.55 (.03) |
| Role physical | 24.6 | 33.1 | 47.8 | 43.2 | 9.05 (.003) |
| Role emotional | 30.6 | 37.2 | 36.0 | 37.7 | 0.57 |
| Pain | 48.8 | 20.3 | 55.0 | 26.7 | 1.41 |
| Vitality | 30.2 | 19.1 | 33.7 | 19.5 | 3.58 (.06) |
| Mental health | 53.2 | 16.3 | 52.6 | 17.6 | 1.25 |
| Social functioning | 53.8 | 26.2 | 61.0 | 25.8 | 4.23 (.04) |
PAB = Patient Attitudes and Beliefs Scale, SCL = Hopkins Symptom Checklist-57 scales, SF-36 = Medical Outcomes Study Short-Form 36 Scale.