Second-Generation Antipsychotics and Metabolic Derangement5
| Drug | Weight Gain | Risk for Diabetes | Worsening Lipid Profile |
|---|---|---|---|
| Clozapine | +++ | + | + |
| Olanzapine | +++ | + | + |
| Risperidone | ++ | D | D |
| Quetiapine | ++ | D | D |
| Aripiprazole* | ± | – | – |
| Ziprasidone* | ± | – | – |
↵* Newer drugs with limited data.
+, increased effect (the more + symbols the greater the effect); –, no effect; D, discrepant results.
Copyright © 2004 American Diabetes Association. From Diabetes Care®, Vol. 27, 2004; 596–601. Reprinted with permission from The American Diabetes Association.