Evidence-based Associations of Obstructive Sleep Apnea (OSA)
| OSA Type | Associated Morbidity | Ranking |
|---|---|---|
| Adult OSA | Obesity | A–consistent systemic meta-analyses4,5 |
| Cognitive impairment (daytime sleepiness) | A–consistent systemic meta-analyses5,7 | |
| Motor vehicular accidents | A–consistent systemic meta-analyses12,13 | |
| Hypertension | A–cross-sectional analysis of prospective cohort studies, consistent systemic meta-analyses10,14 | |
| Increased mortality | B–retrospective cohort studies8,12 | |
| Congestive heart failure (right and left sided) | B–cross-sectional analysis of prospective cohort studies, inconsistent systemic meta-analyses8 | |
| Coronary artery disease | B–cross-sectional analysis of prospective cohort studies, retrospective diagnostic cohort study8 | |
| Cerebral vascular accidents | B–cross-sectional analysis of prospective cohort studies, retrospective cohort study8 | |
| Metabolic syndrome | B–cross-sectional analysis of prospective cohort studies, retrospective cohort studies9,18 | |
| Diabetes | C–retrospective cohort studies9,18 | |
| Cardiac arrhythmias | C–case series, usual practice19 | |
| Pediatric OSA | Obesity | C–retrospective cohort studies20 |
| Enuresis | C–retrospective cohort studies21 | |
| Poor school performance | C–retrospective cohort studies20,22 | |
| Failure to thrive | C–case series, usual practice22 | |
| Learning disability | C–retrospective cohort studies22 | |
| Attention deficit/hyperactivity disorder | C–inconsistent retrospective cohort studies21,23 |