Results of Cox Regression Model for Drug Discontinuation, Controlling for Demographics, Year of Initial Prescription (2001 as Referent), and Concomitant Treatment Regimens*
| Variable | Hazard Ratio (95% CI) | Value of P between Groups |
|---|---|---|
| Demographics | ||
| Age | 0.99 (0.99–0.99) | <.001 |
| Gender (male) | 0.95 (0.93–0.99) | .008 |
| Year of initial prescription (vs. 2002) | 0.91 (0.88–0.94) | <.001 |
| Charlson Comorbidity Index | 1.17 (1.15–1.20) | <.001 |
| Treatment† | ||
| Hydrochlorothiazide | 1.53 (1.47–1.61) | <.001 |
| Amlodipine | 1.32 (1.26–1.39) | <.001 |
| Lisinopril | 1.14 (1.09–1.20) | <.001 |
| Concomitant Treatment Regimens | ||
| Antidyslipidemics | 0.88 (0.85–0.91) | <.001 |
| Antiplatelet agents | 1.08 (1.01–1.15) | .017 |
| Beta-blockers | 0.96 (0.92–0.99) | .009 |
| Digoxin | 1.18 (1.07–1.29) | <.001 |
| Nitroglycerin | 1.35 (1.16–1.58) | <.001 |
| Warfarin | 1.05 (0.98–1.14) | .167 |
* Cox proportional hazards model with Efron approximation method.
† Referent treatment = valsartan.