Table 2.

MRI in Staging of Breast Cancer

StudyType of StudyStudy PopulationNMajor Findings/Comments
Boetes et al.23RetrospectivePatients with invasive lobular carcinoma treated surgically34 (36 cases of breast cancer)False negative rate for MRI was 0% compared with 3% and 14% for US and XRM, respectively; when 2 radiologists retrospectively reviewed the exam results, the percentage of correctly identified size of cancer was 47% and 75% for MRI (r = 0.81, P < .01); this was the most accurate and most highly correlated method
Schelfout et al.17ProspectiveWomen with lesions on XRM, US, and/or CBE21296%, 37%, and 41% of multifocal disease was detected by MRI, XRM, and US, respectively; 95%, 18%, and 9% of multicentric disease was detected by MRI, XRM, and US, respectively; 100% of bilateral breast cancers were seen on MRI; 56% of bilateral breast cancers were seen on XRM and US
Van Goethem et al.24ProspectivePatients with dense breasts planning to undergo surgery6765/67 patients had breast cancer confirmed pathologically; MRI was 98% sensitive for initial lesion compared with 83% and 70.8% for XRM and US, respectively; extent of cancer was underestimated by 12.5% of MRI results as opposed to 37% and 40% for XRM and US results, respectively; multifocal/multicentric disease was picked up 100% of the time by MRI as opposed to 35% and 30% of XRM and US, respectively
Bedrosian et al.18RetrospectivePatients diagnosed with invasive breast cancer who had MRI preoperatively267MRI was 95% sensitive for detecting primary breast cancer; planned management of 26% of patients (N = 69) were changed due to MRI results—in 49/69 (71%) of the patients, postsurgical pathology confirmed that the change in management was appropriate
Rieber et al.28ProspectivePatients suspected of having breast malignancy based on results of XRM, US, or CBE43Sensitivity of MR mammography for diagnosis of primary cancer, contralateral cancer, and multifocal disease was 100%, 100%, and 95.2%; similar values were 93%, 100%, and 92.5% for PET, respectively
Fischer et al.20ProspectivePatients with breast abnormalities after XRM, CBE, PE, and US46366 patients (14.3%) had their planned therapy accurately changed as a result of MRI of the breast with 16 patients (3.5%) undergoing unneeded open biopsy
Esserman et al.21ProspectivePatients with breast cancer with planned surgical correction57 (58 cases of breast cancer)Preoperative MRI identified degree of disease accurately in 54/58 cases of breast cancer; anatomic detail identified on MRI was accurate 98% of the time whereas anatomic detail identified on XRM was accurate in 55% of cases
Rodenko et al.22RetrospectivePatients with infiltrating lobular carcinoma who had MRI and XRM performed preoperatively20Postoperative pathology correlated with preoperative MRI findings in 85% of patients; The correlation with preoperative XRM was 32% (P < .0001)