Table 2.

Trials Involving Clopidogrel Combination Therapies That Are in Progress*

CHARISMAInvestigating the effects of adding clopidogrel 75 mg/day to low-dose aspirin (75 to 162 mg) in patients at high risk of developing atherothrombotic events.49 Completed in July 2005; results pending.
SPS3Investigating the effects of aspirin 325 mg/day or aspirin 325 mg/day + clopidogrel 75 mg/day in the prevention of secondary stroke, major vascular events, and cognitive decline among patients with small subcortical strokes.
This study is also comparing a standard (130 to 149 mm Hg systolic) blood pressure against an aggressive (<130 mm Hg systolic) blood pressure target, and it is evaluating cognitive status in addition to recurrent stroke as an endpoint.
PRoFESSThis study compares clopidogrel (± telmisartan) therapy with aspirin + dipyridamole (± telmisartan) for secondary stroke prevention.
FASTERThe trial will involve patients randomized to receive clopidogrel (or placebo) and simvastatin (or placebo) within 12 hours of onset of TIA or minor stroke; all patients will receive aspirin.
The only clinical stroke trial to include a loading dose of clopidogrel, as was used in the CURE acute coronary syndrome trial.