Clinical Highlights of Patients with Previously Unrecognized KS Diagnosed during Cytogenetic Testing
| Patient | Age at Presentation (years) | Karyotype | Initial Diagnosis | Final Diagnosis | Physical Findings Relevant to KS | Marital Status, Children | Other |
|---|---|---|---|---|---|---|---|
| 1 | 56 | 47,XXY | Thrombo-cytopenia | ITP* | Tall with long legs | Married, two adopted children | Alcoholism, drug addiction, depression, NIDDM |
| 2 | 56 | 47,XXY | AML | AML | Gynecomastia, atrophic testes, female pattern of hair distribution | Never married, no children | Major depression, alcoholism, mild retardation, NIDDM, venous thromboembolism |
| 3 | 48 | 47,XXY | NHL | NHL, diffuse large cell | Small, atrophic testes; tall, long arms; no gynecomastia; normal beard, body hair, & apparent build (yet pt indicated increased central fat, even as child) | Widower; wife had history of 1 miscarriage | Chronic back pain, infertility, depression, multiple dental caries |
| 4 | 67 | 47,XXY | CLL | CLL | Gynecomastia | Married, 1 stepson | Back pain, 8th grade education, NIDDM, dementia |
| 5 | 56 | 47,XXY | CML | CML | None noted | Married, “3 healthy sons” | No mention of KS in patient’s records; only in cytogenetic report |
* ITP, idiopathic thrombocytopenic purpura; NIDDM, non-insulin-dependent diabetes mellitus; AML, acute myeloid leukemia; NHL, non-Hodgkin lymphoma; CLL, chronic lymphocytic leukemia; CML, chronic myelogenous leukemia.