Evidence
| Key Clinical Recommendation | Strength of Recommendation | Reference(s) | Comment and References |
|---|---|---|---|
| A lifestyle intervention aimed at inducing 5%–7% weight loss can prevent type 2 diabetes in patients with IGT | A | 8, 9 | Recommendation based on two large randomized clinical trials. References 10–13 are less powerful but supporting. |
| Metformin can help to prevent type 2 diabetes, especially in younger, more obese patients with IGT | B | 8 | Recommendation based on one large randomized clinical trial. |
| Acarbose can help to prevent type 2 diabetes in patients with IGT | B | 14 | Recommendation based on one randomized clinical trial. |
| Orlistat can help to prevent type 2 diabetes in obese patients with IGT | B | 15, 16 | Recommendation based on one randomized clinical trial and one meta-analysis of three other clinical trials. |
For further explanation of strength of recommendation, see Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. J Am Board Fam Pract 2004;17:59–67.