Clinical Uses and Recommendations
| Clinical Use | Dosage | Comments | Strength of Recommendation |
|---|---|---|---|
| Secondary prevention of cardiovascular disease | 1–2 g/day | May encourage dietary intake, or fish oil supplementation | A19,20 |
| Hypertriglyceridemia | Initial 2–4 g; up to 12 g | For doses greater than 3 g, consider monitoring for bleeding side effects, LDL, and glycemic response | A23 |
| Rheumatoid arthritis | 2.6–6 g may initiate at 90 mg/kg; maintenance dose 45 mg/kg | May take 8–12 weeks for clinical response; consider tapering NSAIDs; compliance may be an issue | A29,30 |
| Infants (not breast-feeding) | 0.35% of dietary fat as DHA | Consider Ω-3 and Ω-6 enriched infant formula | B42,43 |
| Women (pregnant and of childbearing age) | 2 fatty fish meals a week (up to 12 oz) | Avoid shark, tile fish, king mackerel, swordfish. Limit albacore tuna to 6 oz per week. | C47,48,66 |