Commonly Used Step 2 Agents
| Drug | Examples of Brand Name | Usual Adult Dose* | Cost† |
|---|---|---|---|
| Opioid Analgesic Combination (Controlled Drug Schedule) | |||
| Codeine/APAP (C-III) | Tylenol #2 15/300, Tylenol #3 30/300, Tylenol #4 60/300; Liquid 12/120/5 mL (c-v) | 60 mg q 3–4 hours or 1–2 tab q4 hours; 15 mL q 4 hours | $7–14/30s$6–10/120 mL |
| Codeine/aspirin (C-III) | Empirin #3 30/325, Empirin #4 60/325 | 60 mg q 3–4 hours or 1–2 tab q 4 hours | $5–8/30s |
| Hydrocodone/APAP (C-III) | Lorcet-HD 5/500, Lorcet plus 7.5/650, Lorcet 10/650; Lortab 2.5/500, 5/500, 7.5/500; Vicodin 5/500, Vicodin ES 7.5/750, Vicodin HP 10/660; Lortab elixir 2.5/167/5 mL | 10 mg q 3–4 hours or 1–2 tab q 3–4 hours | $14–25/30s |
| Hydrocodone/ibuprofen (C-III)‡ | Vicoprofen 7.5/200 | 1 tab q 4–6 hours | $32.55/30s |
| Oxycodone/APAP (C-II) | Percocet 2.5/325, 5/325, 7.5/500, 10/650; Roxicet 5/325, 5/500; Tylox 5/500 | 10 mg q 3–4 hours | $6–24/30s |
| Oxycodone/aspirin (C-II) | Percodan-Demi 2.5/325, Percodan 5/325 | 10 mg q 3–4 hours | $7–17/30s |
| Propoxyphene napsylate/APAP (C-IV) | Darvocet-N 50 50/325, Darvocet-N 100 100/650 | 100 mg q 4 hours | $9–16/30s |
| Propoxyphene/APAP (C-IV) | Wygesic 65/650 | 1 tab q 4 hours | $6–9/30s |
| Other Step 2 Agents | |||
| Tramadol‡ | Ultram 50 mg | 50–100 mg q 4–6 hours | $25/30s |
| Tramadol/APAP‡ | Ultracet 37.5/325 | 1–2 tab q 4–6 hours | $25/30s |
* The total dose of acetaminophen or aspirin should be <4 g/day.
† Cost based on generic pricing listed in 2001 Drug Topics Redbook.
‡ Not available in generic.
APAP, acetaminophen; q, every.