Opioid Equianalgesic Dosing Chart
| Drug (Common Trade Name) | Dose (mg) Equianalgesic to 10 mg SC/IV Morphine | SC/IV:PO ratio | Duration of Action (Hours) | |
|---|---|---|---|---|
| SC/IV | PO/PR | |||
| Morphine (MSIR, Roxanol) | 10 | 30* | 3:1 | 3–4 |
| Codeine (with aspirin or APAP) | 130 | 180–200 | 1.5: 1 | 3–4 |
| Hydrocodone (in Lortab, Vicodin, others) | NA | 30 | NA | 3–4 |
| Hydromorphone (Dilaudid) | 1.5 | 7.5 | 5:1 | 3–4 |
| Levorphanol (Levo-Dromoran) | 2 | 4 | 2:1 | 6–8 |
| Meperidine (Demerol) | 100 | 300 | 3:1 | 3 |
| Methadone (Dolophine, others) | 10 for acute 2–4 for chronic | 20 for acute 2–4 for chronic | 2:1† | 6–8‡ |
| Oxycodone (Roxicodone, also in Percocet, Percodan, others) | NA | 30 | NA | 3–4 |
* IV/PO ratio (1:3) is based on chronic dosing. IM/PO ratio of 1:6 for single dose or intermittent dosing.
† Oral administration results in delayed onset and lower peak.
‡ Duration and half-life increase with chronic dosing.
APAP, acetaminophen; IM, intramuscular; PO, by mouth; SC, subcutaneous; IV, intravenous.