Table 1.

Comparison of the Conversion Rates of Ibutilide, Amiodarone, Propafenone, Procainamide, Dofetilide, and Flecainide in Recent-Onset Atrial Fibrillation, Persistent Atrial Fibrillation, and Recent-Onset Atrial Flutter

Pharmacological Agent	Conversion Rates (%)
Pharmacological Agent	Recent-Onset Atrial Fibrillation	Persistent Atrial Fibrillation/Flutter	Recent-Onset Atrial Flutter
Ibutilide	31–77^11,16,18	48¹²	63–76^17,22
Amiodarone	34–69 (with bolus regimen)²³	15–48^24–29	29¹⁶
Amiodarone	55–95 (with bolus followed by continuous infusion)	15–48^24–29	29¹⁶
Propafenone	56–87.5^30,31	37.5–40^31,32	40³³
Procainamide	20–60^34,35		14³⁶
Dofetilide	24³⁷	20 (dose of 125 mcg bid)	64³⁷
		44 (250 mcg bid)
		85 (500 mcg bid) ³⁸
		66.7 atrial flutter³⁹
Flecainide	57–68 (at 2–4 hr)^18,40		13 (with intravenous administration)⁴¹
Flecainide	75–91 (at 8 hr)⁴⁰		13 (with intravenous administration)⁴¹