Differences in Biophysical and Metabolic Parameters among Matched Pairs of Patients (n = 11) with and without Acanthosis Nigricans (AN)
| No AN | AN | Difference | P* | |
|---|---|---|---|---|
| Body mass index† | 36.2 (1.6) | 38.2 (1.6) | 2.0 (1.0) | — |
| Waist circumference (9 pairs) | 112 (3) | 113 (4) | 1 (3) | .71 |
| Systolic blood pressure (8 pairs) | 128 (5) | 128 (9) | −0 (13) | .99 |
| Diastolic blood pressure (9 pairs) | 85 (2) | 87 (4) | 2 (5) | .66 |
| Glucose | 91 (3) | 94 (4) | 3 (5) | .56 |
| Triglyceride | 135 (22) | 145 (13) | 10 (24) | .70 |
| Cholesterol | 197 (8) | 190 (6) | −7 (12) | .59 |
| High-density lipoprotein | 44 (4) | 42 (3) | −2 (5) | .74 |
| Low-density lipoprotein | 127 (8) | 120 (6) | −7 (12) | .57 |
| Insulin‡ | 13.1 (1.5) | 23.0 (4.0) | 9.9 (3.9) | .02 |
| Free fatty acids (10 pairs) | 0.57 (0.04) | 0.53 (0.07) | −0.04 (0.08) | .63 |
| Homeostasis model assessment‡ | 2.98 (0.37) | 5.57 (1.12) | 2.58 (1.07) | .03 |
Values provided as mean (SE).
* P values for insulin and homeostasis model assessment are from Wilcoxon signed rank tests. All others are paired t tests.
† Body mass index was a matching variable so was not tested for significance.
‡ Geometric means of insulin: 12.3 for no AN; 19.7 for AN. Geometric mean of homeostasis model assessment: 2.7 for no AN; 4.6 for AN.