Table 2.

Diagnostic Validity of the Two-Item Patient Health Questionnaire for the Edinburgh Postnatal Depression Scale*

Variable(s)AUROC Curve (95% CI)Sensitivity (%)Specificity (%)PPV (%)NPV (%)
EPDS ≥13
    15 weeks' EGA
        PHQ-20.80 (0.69–0.91)93754498
        PHQ-2 and history of depression0.85 (0.76–0.94)
        Cut point 1/297615991
        Cut point 258922199
    30 weeks' EGA
        PHQ-20.81 (0.74–0.88)82802491
        PHQ-2 and history of depression0.85 (0.76–0.94)
        Cut Point 1/293634291
        Cut Point 241912298
        PHQ-20.83 (0.68–0.98)80863098
        PHQ-2 and history of depression0.83 (0.70–0.97)
        Cut point 1/290674496
        Cut point 260961199
  • * Edinburgh Postnatal Depression Scale (EPDS) score ≥13.

  • PHQ-2, 2-item Patient Health Questionaire; AUROC, area under the receiving operator characteristic; PPV, positive predictive value; NPV, negative predictive value; EGA, estimated gestational age; Cut point 1/2, one of 2 screening items positive; Cut point 2, both screening items positive.