Diagnostic Validity of the Two-Item Patient Health Questionnaire for the Edinburgh Postnatal Depression Scale*
| Variable(s) | AUROC Curve (95% CI) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|
| EPDS ≥13 | |||||
| 15 weeks' EGA | |||||
| PHQ-2 | 0.80 (0.69–0.91) | 93 | 75 | 44 | 98 |
| PHQ-2 and history of depression | 0.85 (0.76–0.94) | ||||
| Cut point 1/2 | 97 | 61 | 59 | 91 | |
| Cut point 2 | 58 | 92 | 21 | 99 | |
| 30 weeks' EGA | |||||
| PHQ-2 | 0.81 (0.74–0.88) | 82 | 80 | 24 | 91 |
| PHQ-2 and history of depression | 0.85 (0.76–0.94) | ||||
| Cut Point 1/2 | 93 | 63 | 42 | 91 | |
| Cut Point 2 | 41 | 91 | 22 | 98 | |
| Postpartum | |||||
| PHQ-2 | 0.83 (0.68–0.98) | 80 | 86 | 30 | 98 |
| PHQ-2 and history of depression | 0.83 (0.70–0.97) | ||||
| Cut point 1/2 | 90 | 67 | 44 | 96 | |
| Cut point 2 | 60 | 96 | 11 | 99 |
* Edinburgh Postnatal Depression Scale (EPDS) score ≥13.
PHQ-2, 2-item Patient Health Questionaire; AUROC, area under the receiving operator characteristic; PPV, positive predictive value; NPV, negative predictive value; EGA, estimated gestational age; Cut point 1/2, one of 2 screening items positive; Cut point 2, both screening items positive.