Characteristics of Subjects Who Had No Diseases Known to Cause Peripheral Neuropathy and Who Were Still Enrolled in the Third Year of the Study (N = 287)
| Continuous Variables | PN(−) N = 225 Mean (SD) | PN(+) N = 62 Mean (SD) | T | P Value |
|---|---|---|---|---|
| Age | 72.90 (5.56) | 72.77 (5.16) | 0.17 | .87 |
| BMI | 28.11 (4.79) | 29.93 (6.10) | −2.16 | .03 |
| Pulse pressure | 64.13 (17.93) | 63.81 (15.15) | 0.14 | .89 |
| Otho BP | 11.50 (0.92) | 13.60 (11.06) | −1.25 | .21 |
| Diast BP(5 Rest) | 75.03 (10.43) | 75.45 (11.97) | −0.25 | .80 |
| Diast BP(1 Stand) | 74.55 (11.07) | 75.90 (14.21) | −0.69 | .49 |
| Diast BP(5 Stand) | 74.69 (12.38) | 76.30 (13.29) | −0.85 | .40 |
| Syst BP(5 Rest) | 139.16 (19.22) | 139.26 (21.32) | −0.03 | .97 |
| Syst BP(1 Stand) | 133.25 (21.94) | 135.05 (23.00) | −0.55 | .59 |
| Syst BP(5 Stand) | 134.44 (20.46) | 135.41 (21.41) | −0.32 | .75 |
| Categorical Variables | State | PN(−) | PN(+) | χ2 | P Value |
|---|---|---|---|---|---|
| Gender | Female | 124 | 30 | 0.88 | .35 |
| Male | 101 | 32 | |||
| Hypertension | (−) | 134 | 37 | 0.00 | .99 |
| (+) | 91 | 25 | |||
| ACE-I & ARB* | (−) | 181 | 49 | 0.06 | .81 |
| (+) | 44 | 13 | |||
| α blocking agents | (−) | 207 | 56 | 0.18 | .67 |
| (+) | 18 | 6 | |||
| β blocking agents | (−) | 209 | 49 | 10.27 | .001 |
| (+) | 16 | 13 | |||
| Calcium channel block | (−) | 203 | 55 | 0.12 | .73 |
| (+) | 22 | 7 | |||
| Diuretics | (−) | 187 | 48 | 1.06 | .30 |
| (+) | 38 | 14 | |||
| Vasodilators | (−) | 218 | 62 | 1.98 | .16 |
| (+) | 7 | 0 | |||
| NSAIDs | (−) | 190 | 42 | 8.75 | .003 |
| (+) | 35 | 20 | |||
| Military service | (−) | 146 | 36 | 0.98 | .32 |
| (+) | 79 | 26 | |||
| Number of medications | 0 | 138 | 30 | 3.61 | .16 |
| 1 | 45 | 15 | |||
| 2 or more | 42 | 17 | |||
| Logistic Regression |
| Predictor Variables | Coefficient | Standard Error | P Value | Deviance (P Value) |
|---|---|---|---|---|
| BMI | 0.05 | 0.03 | .07 | |
| β-blocking agents | 1.29 | 0.42 | .002 | 277.20 |
| NSAID | 0.84 | 0.34 | .01 | (P = .52) |
* ACE-I & ARB, angiotensin-converting enzyme inhibitor and angiotensin receptor blocker; BMI, body mass index; NSAIDs, nonsteroidal antiinflammatory drugs.