Cases at Moderate or High Genetic Risk for Cancer*
| Cancer Type | Genetic Risk | Criteria | ↑ Risk Noted by PCP† |
|---|---|---|---|
| Breast-ovarian | High | Index patient with bilateral breast CA, onset <40 years | No |
| Breast-ovarian | High | SDR with both breast and ovarian CA | No |
| Breast | Moderate | 1 FDR and 1 SDR, sum of ages <118 years | Yes |
| Colon | High | 1 FDR with CRC <50 years and 1 FDR with CRC and 1 SDR with CRC | No |
| Colon | High | SDR with CRC and SDR with endometrial CA and SDR with ovarian CA | No |
| Colon | High | 3 SDRs with CRC | Yes |
| Colon | High | FDR with pancreatic CA and 2 SDRs with endometrial CA | No |
| Colon | Moderate | 2 FDRs with CRC | Yes |
| Prostate | Moderate | FDR <60 years | No |
| Melanoma | High | Index patient with multiple primary melanomas | No |
* As determined by Hampel et al criteria.5
† PCP, primary care physician; CA, cancer; FDR, first degree relative; SDR, second degree relative; CRC, colorectal cancer.