Associations between 1 or More and 2 or More Bilateral Peripheral Neurologic Deficits and Various Outcomes after Adjusting for Age, Gender, Race, Education, Income, Body Mass Index, and Presence of Disease Known to Cause Peripheral Neuropathy
| Outcome Variables | 1 + Deficit | 2 + Deficits |
|---|---|---|
| Symptoms | ||
| Numbness arms/legs | 1.44 (0.97, 2.14) | 2.74 (1.56, 4.79)* |
| Pain or discomfort | 1.68 (1.19, 2.37)* | 1.80 (1.03, 3.16)* |
| Restless legs | 1.40 (0.96, 2.04) | 2.15 (1.23, 3.74)* |
| Trouble walking | 1.50 (1.04, 2.17)* | 2.62 (1.47, 4.67)* |
| Trouble with balance | 1.64 (1.11, 2.43)* | 2.65 (1.50, 4.70)* |
| Falls in last 3 months | ||
| One fall | 1.22 (0.80, 1.84) | 1.07 (0.56, 2.03) |
| ≥2 falls | 1.53 (0.83, 2.81) | 1.17 (0.46, 2.97) |
| Objective Findings | ||
| Tinetti Balance Score (0 to 16) | −1.12 (−1.54, −0.70)* | −1.58 (−2.26, −0.91)* |
| Timed 50−ft walk (seconds) | −0.12 (−1.15, 0.91) | −0.08 (−1.73, 1.56) |
| QOL/Functional Status | ||
| Self rated health (0 to 100) | −0.82 (−3.53, 1.89) | −2.55 (−6.87, 1.77) |
| SF-36 General Health (0 to 100) | −2.42 (−5.47, 2.63) | −6.65 (−11.48, −1.83)* |
| SF-36 Physical Functioning(0 to 100) | −7.06 (−11.01, −3.10)* | −10.54 (−16.89, −4.18)* |
| SF-36 Role Physical (0 to 100) | −5.09 (−11.73, 1.55) | −8.16 (−18.76, 2.44) |
| SF-36 Bodily Pain (0 to 100) | −3.36 (−7.22, 0.49) | −5.96 (−12.09, 0.17) |
| QWB-SA (0 to 1) | −0.027 (−0.047, −0.006)* | −0.028 (−0.61, 0.004) |
| HUI-3 (0 to 1) | −0.039 (−0.074, −0.004)* | −0.046 (−0.102, 0.010) |
Odds ratios and 95% confidence intervals derived from logistic regression models are given for symptoms β coefficients and 95% confidence intervals derived from linear regression models are given for objective findings and QOL/functional status. Numbers are odds ratios (95% confidence intervals) for symptom variables and β coefficients (95% confidence intervals) for all other variables.
* P < .05
QWB-SA, Quality of Well Being–Self-Administered Scale; HUI-3, Healthy Utility Index 3 Scale.