Comorbid Conditions in Heart Failure with Reduced Ejection Fraction
| Comorbid Condition | Recommendation | Evidence Rating |
|---|---|---|
| Hypertension | Uptitration of medications according to GDMT to maximum tolerated dosages | SORT A1 |
| Diabetes | SGLT2i as initial therapy for hyperglycemia | SORT A10 |
| Iron deficiency | Intravenous iron repletion | SORT B9 |
| Central Sleep Apnea | Adaptive servo-ventilation should not be used as it increases mortality | SORT A1 |
| Atrial fibrillation | Guideline directed management should be pursued, including consideration of rhythm control and left atrial appendage closure in select patients | SORT A vs B depending on component of therapy1 |
| Valvular heart disease | Manage according to current guidelines | See relevant guideline11 |
| Ischemic heart disease | Should be considered in cases of HF to facilitate diagnosis and management | SORT B1 |
Abbreviations: HF, Heart failure; GDMT, guideline-directed medical therapy.