Potential Adverse Events in Breastfed Infants Exposed to Selective Serotonin Reuptake Inhibitors During Lactation
| Individual SSRI | Prevalence Rate* | Reported Adverse Events* |
|---|---|---|
| Sertraline | 2/280 cases (∼0.7%) | Sleep myoclonus, agitation, restlessness, poor feeding, insomnia |
| Paroxetine | 2/228 cases (∼0.9%) | Irritability, lethargy, poor weight gain, hypotonia |
| Citalopram | 6/112 cases (∼5.4%) | Colic, decreased feeding, irritability/restlessness, sleep disturbances, hypo/hypertonia, irregular breathing |
| Fluoxetine | 11/280 cases (∼3.9%) | Colic, seizures, irritability/restlessness, somnolence, lethargy, fever, unresponsiveness, watery stool, uncontrollable crying, vomiting, poor sleep |
| Escitalopram | 1/37 cases (∼2.7%) | Necrotizing enterocolitis |
| Fluvoxamine | 1/18 cases (∼5.6%) | Jaundice |
Abbreviation: SSRIs, Selective serotonin reuptake inhibitors.
*Data obtained from: Orsolini L, Bellantuono C. Serotonin reuptake inhibitors and breastfeeding: a systematic review. Hum Psychopharmacol. 2015;30(1):4-20. doi:10.1002/hup.2451.