Table 2.

Adapted McMaster Harms Evaluation with Best Practice Evaluation

	Bokemeyer	Bretthauer	Causada-Calo	Rabeneck	Zwink	Zafar
Were there harms PRE-DEFINED using standardized or precise definitions?	Yes	No	Yes	Yes	Yes	Yes
Were SERIOUS events precisely defined?	Yes	No	No	No	Yes	No
Were SEVERE events precisely defined?	Yes	No	No	No	No	No
Were the number of DEATHS in each study group specified OR were the reason(s) for not specifying them given?	Yes	Yes	Yes	Yes	Yes	Yes
Was the mode of harms collection specified as ACTIVE?	No	No	No	No	Yes	No
Was the mode of harms collection specified as PASSIVE?	Yes	Yes	Yes	Yes	No	Yes
Did the study specify WHO collected the harms?	No	No	Yes	No	Yes	No
Did the study specify the TRAINING or BACKGROUND of who ascertained the harms?	No	No	No	No	No	No
Did the study specify the TIMING and FREQUENCY of collection of the harms?	Yes	Yes	Yes	Yes	Yes	Yes
Did the author(s) use STANDARD scale(s) or checklist(s) for harms collection?	Yes	No	Yes	Yes	No	No
Did the authors specify if the harms reported encompass ALL the events collected or a selected SAMPLE?	All	All	All	All	All	All
Was the NUMBER of participants that withdrew or were lost to follow-up specified for each study group?	N/A	Yes	N/A	N/A	Yes	N/A
Was the TOTAL NUMBER of participants affected by harms specified for each study arm?	Yes	Yes	Yes	Yes	Yes	Yes
Did the author(s) specify the NUMBER for each TYPE of harmful event for each study group?	Yes	Yes	Yes	Yes	Yes	Yes
Did the author(s) specify the type of analyses undertaken for harms data?	No	No	Yes	Yes	Yes	Yes