Symptom Score Spline Regression Analysis Slope Coefficients
| Coefficient | Std. Err. | P-Value | 95% Interval | |
|---|---|---|---|---|
| First segment slope spline (days 1 to 3) | ||||
| Referent Group (Placebo) | −2.86 | 0.55 | <0.001 | (−3.93, −1.79) |
| Vitamin C | 1.11 | 0.76 | 0.14 | (−0.37, 2.6) |
| Melatonin | 1.23 | 0.77 | 0.11 | (−0.29, 2.74) |
| Second segment slope spline (days 3 to 9) | ||||
| Referent Group (Placebo) | −1.09 | 0.15 | <0.001 | (−1.39, −0.8) |
| Vitamin C | 0.22 | 0.21 | 0.31 | (−0.2, 0.63) |
| Melatonin | −0.63 | 0.22 | 0.003 | (−1.06, −0.21) |
| Third segment slope spline (days 9 to 14) | ||||
| Referent Group (Placebo) | −0.08 | 0.19 | 0.69 | (−0.46, 0.3) |
| Vitamin C | −0.48 | 0.27 | 0.08 | (−1.01, 0.05) |
| Melatonin | −0.04 | 0.28 | 0.88 | (−0.6, 0.51) |
Note: these slope coefficients represent change over a very short period of time, ie 3-4 days.
Correlates with Figure 2.