Characteristics of Methotrexate Ingestions by Humans
| Characteristic | Number | % |
|---|---|---|
| Total calls of ingestions | 111 | 100 |
| Sex | ||
| Male | 32 | 29 |
| Female | 79 | 71 |
| Age (years) | ||
| 0 to 18 | 15 | 14 |
| 19 to 40 | 15 | 14 |
| 41 to 60 | 34 | 31 |
| 61 to 80 | 36 | 32 |
| 81 to 100 | 8 | 7 |
| Not listed/unknown | 3 | 3 |
| Ingestion type | ||
| Intentional | 23 | 21 |
| Unintentional | 88 | 79 |
| Unintentional subtype | ||
| Dose error | 13 | 15 |
| One extra dose | 40 | 45 |
| Multiple extra doses | 27 | 31 |
| Pediatric exploratory | 8 | 9 |
| Medication indication listed | 69 | 62 |
| Rheumatoid arthritis | 38 | 55 |
| Crohn's disease | 5 | 7 |
| Psoriasis or psoriatic arthritis | 14 | 20 |
| Other disease | 12 | 17 |
| Treatment | ||
| Leucovorin treatment | 34 | |
| Intentional ingestion | 12 | 35 |
| Unintentional ingestion | 22 | 65 |
| Sodium bicarbonate | 18 | |
| Activated charcoal | 6 | |
| Blood products | 4 | |
| Steroids | 1 | |
| Granulocyte stimulating factor | 2 | |
| Course | ||
| Ingestions admitted to hospital | 41 | |
| Intentional ingestion | 17 | 41 |
| Unintentional—dose error | 2 | 5 |
| Unintentional—one extra dose | 11 | 27 |
| Unintentional—multiple extra doses | 8 | 20 |
| Unintentional—ediatric exploratory | 3 | 7 |
| Admitted and leucovorin treatment | 31 | 28 |
| Intentional ingestion | 12 | 39 |
| Unintentional ingestion | 19 | 61 |
| Recorded signs of toxicity | 12 | 11 |
| Death | 2 | 2 |