Table 5.

Multisystem Involvement in Patients with HSD2,10,21

Neurologic

  • Migraine headache

  • Tension-type headache

  • Dysautonomia

  • Postural orthostatic tachycardia syndrome

  • Upper limb paresthesias (carpal or cubital tunnel syndromes, thoracic outlet syndrome)

Gastrointestinal

  • Abdominal pain

  • Hiatal hernia

  • Gastroesophageal reflux disease

  • Irritable bowel syndrome

  • Dysphagia

  • Nausea

  • Constipation

  • Crohn's disease

Psychiatric

  • Anxiety

  • Depression

  • Insomnia

Gynecologic

  • Pelvic pain

  • Dysmenorrhea

  • Urinary stress and/or urge incontinence

Other

  • Temporomandibular joint disorders

  • Chronic fatigue syndrome

  • Exercise intolerance

  • Postexercise malaise

  • HSD, Hypermobility spectrum disorder.