Table 6.

Comparing HSD, hEDS, and Other EDS Disorders

Joint hypermobility
Chronic pain
Musculoskeletal pain in more than 2 limbs, back ≥ 3 months
Recurrent joint dislocations
Recurrent hernias, uterine and rectal prolapse
Marfanoid habitus
Mild skin hyperextensibility, striae, atrophic scarring
Skin fragility, pronounced hyperextensibility
Cardiovascular autonomic dysfunction
Mild cardiovascular findings (mild mitral valve regurgitation, aortic root dilation)
Severe cardiovascular findings (aneurysms, arterial rupture)
Positive family history
Molecular genetic findings
  • HSD, Hypermobility spectrum disorder; hEDS, hypermobile Ehlers-Danlos syndrome; EDS, Ehlers-Danlos syndrome.