Table 2. Outpatient Microinduction Protocol Using Sublingual 2 mg Buprenorphine/Naloxone Tablets or Films

DayBup/Nlx Dose and FrequencyFull Agonist Opioid
10.5 mg daily (1/4 tablet or film)No change
20.5 mg BIDNo change
31 mg BID (half-tablet or film)No change
42 mg BIDNo change
52 mg TIDNo change
64 mg TIDNo change
7 and beyondPer provider discretionTaper by 25% weekly

  • Bup, Buprenorphine; Nlx, naloxone; BID, twice a day; TID, twice a day.