Weighted Mean Differences between Patients With and Without the Outcome
| Risk Factor | Studies | Patients | WMD (95% CI) |
|---|---|---|---|
| Outcome = death | |||
| CRP (mg/L) | 4 | 1016 | 40.4 (27.4–53.3) |
| Age (years) | 7 | 1418 | 18.5 (15.4–21.6) |
| D-dimer (mg/L) | 4 | 870 | 7.8 (6.1–9.4) |
| Heart rate (beats/minute) | 3 | 486 | 5.3 (1.7–8.9) |
| Neutrophil count (×109/mL) | 3 | 679 | 4.3 (2.7–5.8) |
| WBC count (×109/mL) | 6 | 1314 | 4.0 (3.4–4.6) |
| Respiratory rate | 3 | 486 | 3.1 (1.5–4.7) |
| Procalcitonin (ng/mL) | 3 | 763 | 0.34 (0.27–0.40) |
| Oxygen saturation (%) | 4 | 823 | −8.9 (−11.9 to −5.9) |
| Lymphocyte count (×109/mL) | 6 | 1314 | −0.41 (−0.50 to −0.32) |
| Outcome = severe disease | |||
| CRP (mg/L) | 4 | 731 | 34.2 (15.4–53.1) |
| Age (years) | 8 | 2223 | 14.1 (10.9–17.6) |
| Neutrophil count (×109/mL) | 5 | 752 | 0.94 (−0.42 to –2.3) |
| WBC count (× 109/mL) | 5 | 954 | 0.73 (−0.63 to 2.1) |
| D-dimer (mg/L) | 5 | 604 | 0.30 (0.06–0.55) |
| Lymphocyte count (×109/mL) | 5 | 948 | −0.44 (−0.52 to −0.36) |
| Outcome = severe disease or death | |||
| CRP (mg/L) | 4 | 4531 | 60.5 (47.9–73.2) |
| Age (years) | 5 | 4641 | 15.9 (10.4–21.3) |
| Neutrophil count (×109/mL) | 4 | 1912 | 2.6 (2.1–3.2) |
| WBC count (×109/mL) | 3 | 322 | 2.0 (0.98–3.0) |
| Procalcitonin (ng/mL) | 3 | 4420 | 0.13 (−0.30 to 0.56) |
| Oxygen saturation (%) | 3 | 2940 | −4.4 (−7.3 to −1.4) |
| Lymphocyte count | 5 | 4641 | −0.63 (−1.0 to −0.22) |
Variables reported by fewer than 3 studies are not included but can be found in the online Appendix B.
WMD, weighted mean differences; WBC, white blood count; CRP, c-reactive protein.