Characteristics of Included Studies
| Author, Year | Country | Patients Studied | Mean or median age | % Male | Definition of Bad Outcome | Mortality Rate, % |
|---|---|---|---|---|---|---|
| Yu, 202032 | China | Adults with COVID-19 from 27 hospitals in Jiangsu Province with a CT scan | 48 (median) | 53.0 | Composite of ICU admission, acute respiratory failure occurrence, or shock during hospitalization | 15.0 |
| Wang, 202033 | China | Adults with COVID-19 who were discharged from 2 hospitals (Wuhan and Hubei Province) | 51 (median) | 53.3 | Death | 17.8 |
| Chen, 202034 | China | Adults with COVID-19 classified as moderately, severely or critically ill in 1 hospital in Wuhan | 68 (median) | 62.4 | Death | 41.2 |
| Zhou, 202035 | China | Adults with COVID-19 who had been discharged or died in 2 Wuhan hospitals | 56 (median) | 62.3 | Death | 28.0 |
| Liu, 202036 | China | Adults with COVID-19 pneumonia in 3 tertiary hospitals in Wuhan | 38 (median) | 50 | Clinical deterioration | 14.1 |
| Liang, 202019 | China | Adults with COVID-19 from 575 hospitals in 31 regions of China | 48.9 (mean) | 57.3 | Composite of admission to ICU, invasive ventilation, death | 3.2 |
| Xie, 202037 | China | Adults with COVID-19 who had been discharged from or died in 2 hospitals in Wuhan | 62 (median) | 53.8 | Death | 50.5 |
| Yan, 202038 | China | Adults with COVID-19 in 1 hospital in Wuhan | 58.83 (mean) | 58.7 | Death | 46.4 |
| Cao, 202039 | China | Adults with COVID-19 in 1 hospital in Shanghai | 50.1 (mean) | 51 | Admission to ICU | NR |
| Hu, 202040 | China | Adults with COVID-19 in 1 hospital in Wuhan | 61 (median) | 51.4 | Death or progression | 10.8 |
| Luo, 202041 | China | Adults with COVID-19 with a clinical outcome in 1 hospital in Wuhan | 57 (median) | 50.3 | Death | 28.2 |
| Petrilli, 202042 | United States | Adults with laboratory confirmed critical COVID-19 in 1 hospital in New York City | 54 (median) | 49.5 | Composite of ICU, mechanical ventilation, discharge to hospice or death. | 24.3 |
| Wu, 202043 | China | Adults with COVID-19 pneumonia in 1 hospital in Wuhan | 51 (median) | 63.7 | ARDS | 21.9 |
| Li, 202044 | China | Adults with laboratory confirmed severe COVID-19 infection | 57 (median) | 58 | Death | 14.7 |
| Jang, 202045 | Korea | Adults with COVID-19 hospitalized at a tertiary hospital in Daegu, Korea | 56.9 (mean) | 43.6 | Compositive of ARDS, ICU care, or death | 7.3 |
| Xu, 202046 | China | Adults with laboratory-confirmed COVID-19 admitted to 16 tertiary hospitals from 8 provinces in China | 46.1 (mean) | 54 | Composite of death, ICU, or requiring mechanical ventilation. | 4.7 |
| Zhou, 202047 | China | Adults with laboratory-confirmed COVID-19 collected from 47 locations in Sichaun | 43 (median) | 56.6 | Vasopressors or respiratory failure + 3 of: respiratory rate >30, PaO2/FIO2 ≤250 mm Hg, infiltrates, confusion, BUN ≥20 mg/dL, leukopenia, hypothermia, thrombocytopenia, or hypotension. | NR |
| Hou, 202048 | China | Adults with laboratory-confirmed COVID-19 hospitalized at Beijing hospitals | 50.9 (median) | 43.6 | Progression defined as having a clinically advanced type of COVID-19, ICU admission, or death during hospitalization | 5.0 |
| Zhang, 202049 | China | Adults with laboratory-confirmed COVID-19 in 1 hospital in Wuhan, China | 38.0 (median) | 41.4 | Disease deterioration including the transfer to ICU and death | 13.5 |
| Liu, 202050 | China | Adults with laboratory-confirmed COVID-19 in 1 hospital in Wuhan, China | 65.5 (median) | 35.0 | Severe disease defined as having shortness of breath, RR ≥30 bpm, O2 sat ≤93%, PaO2/FIO2 ≤ 300 mm Hg, and progression on imaging | NR |
| Zhu, 202051 | China | Adults with confirmed COVID-19 at 1 hospital in Zhejiang, China | 50.9 (mean) | 35.4 | Severe disease defined as shortness of breath, RR ≥30 bpm, O2 sat ≤93%, PaO2/FIO2 ≤300 mm Hg, or lesion progression | NR |
| Hu, 202052 | China | Adults with laboratory-confirmed critical COVID-19 in 1 hospital in Wuhan, China | 60.8 (mean) | 50.9 | Death | 18.0 |
COVID-19, coronavirus 2019; CT, computed tomography; RR, respiratory rate; O2 sat, oxygen saturation; BUN, blood urea nitrogen; ICU, intensive care unit; ARDS, acute respiratory distress syndrome.