Table 2.

Manufacturer's Recommended Starting Dose and Conversion to Longer-Acting Basal Insulins from Other Basal Insulin Treatments for Patients with Type 2 Diabetes9397

Basal Insulin Patient Is Converting toInsulin Glargine 100 U/mLInsulin DetemirLY2963016 (Insulin Glargine 100 U/mL Alternative)Insulin Glargine 300 U/mLInsulin Degludec 100 U/mL or 200 U/mL
Starting dose for insulin-naïve patients with T2D10 units (or 0.2 units per kg body weight) once daily10 units (or 0.1 to 0.2 units per kg body weight) once daily in the evening or twice daily0.2 units per kg body weight or up to 10 units once daily0.2 units per kg body weight10 units once daily
Conversion ratio from other basal insulin treatments1:1 for once daily NPH1:1 for NPH or insulin glargine1:1 for insulin glargine 100 units/mL1:1 for once daily, long- or intermediate-acting basal insulin1:1 for once daily basal insulin
80% for twice daily NPH80% for insulin glargine 300 units/mL or twice daily NPH80% of daily NPH
Titration recommendations*Adjustments should be made according to blood glucose measurementsAdjustments should be made according to blood glucose measurementsTitrate based on metabolic needs, blood glucose measurements, and glycemic control goal3 to 4 days between dose increasesAdjust and titrate over 3 to 4 days
Decrease 2 units if below FPG goal, 0 units if within FPG goal, and increase 2 units if above FPG goalShould be individualized to patient needs and FPG goals
  • * These should be individualized to patient needs.

  • FPG, fasting plasma glucose; T2D, type 2 diabetes.