Table 2.

Manufacturer's Recommended Starting Dose and Conversion to Longer-Acting Basal Insulins from Other Basal Insulin Treatments for Patients with Type 2 Diabetes^93–97

Basal Insulin Patient Is Converting to	Insulin Glargine 100 U/mL	Insulin Detemir	LY2963016 (Insulin Glargine 100 U/mL Alternative)	Insulin Glargine 300 U/mL	Insulin Degludec 100 U/mL or 200 U/mL
Starting dose for insulin-naïve patients with T2D	10 units (or 0.2 units per kg body weight) once daily	10 units (or 0.1 to 0.2 units per kg body weight) once daily in the evening or twice daily	0.2 units per kg body weight or up to 10 units once daily	0.2 units per kg body weight	10 units once daily
Conversion ratio from other basal insulin treatments	1:1 for once daily NPH	1:1 for NPH or insulin glargine	1:1 for insulin glargine 100 units/mL	1:1 for once daily, long- or intermediate-acting basal insulin	1:1 for once daily basal insulin
	80% for twice daily NPH		80% for insulin glargine 300 units/mL or twice daily NPH		80% of daily NPH
Titration recommendations^*	Adjustments should be made according to blood glucose measurements	Adjustments should be made according to blood glucose measurements	Titrate based on metabolic needs, blood glucose measurements, and glycemic control goal	3 to 4 days between dose increases	Adjust and titrate over 3 to 4 days
				Decrease 2 units if below FPG goal, 0 units if within FPG goal, and increase 2 units if above FPG goal	Should be individualized to patient needs and FPG goals

↵* These should be individualized to patient needs.
FPG, fasting plasma glucose; T2D, type 2 diabetes.