Table 3.

Direct Oral Anticoagulant Characteristics: Interruption and Reversal54

CharacteristicsDabigatranRivaroxabanApixabanEdoxaban
MechanismIIa inhibitorXa inhibitorXa inhibitorXa inhibitor
Specific reversal agents (first line)Praxbind (idarucizumab)AndexanetAndexanetAndexanet
Alfa*Alfa*Alfa*
Ciraparantag*Ciraparantag*Ciraparantag*
Second line reversal agentsaPCCaPCCaPCCaPCC
4F- PCC
  • aPCC, activated prothrombin complex concentrate; 4F-PCC = 4 factor prothrombin complex concentrate.

  • * Not commercially available in the USA.