Table 2B.

Recommended Durations for Interrupting Oral Factor Xa Inhibitor in the Preprocedural Setting: Apixaban, Edoxaban, and Rivaroxaban57,7476

Creatinine Clearance (ml/min)Estimated Half-Life (hours)Duration of Interruption
Low PBRIntermediate/High/Uncertain PBR
≥306 to 15≥24 hours≥48 hours
15 to 29Apixaban: 17≥36 hoursNo data
Edoxaban: 17Consider ≥72 hours*
Rivaroxaban: 9
<15Apixaban: 17No dataNo data
Edoxaban: 10 to 17Consider ≥48 hours*Consider ≥72 hours*
Rivaroxaban: 13
  • PBR, procedural bleeding risk.

  • * Consider measuring agent-specific anti-Xa level.

  • Off dialysis.