Table 2B.

Recommended Durations for Interrupting Oral Factor Xa Inhibitor in the Preprocedural Setting: Apixaban, Edoxaban, and Rivaroxaban^57,74–76

Creatinine Clearance (ml/min)	Estimated Half-Life (hours)	Duration of Interruption
Creatinine Clearance (ml/min)	Estimated Half-Life (hours)	Low PBR	Intermediate/High/Uncertain PBR
≥30	6 to 15	≥24 hours	≥48 hours
15 to 29	Apixaban: 17	≥36 hours	No data
	Edoxaban: 17		Consider ≥72 hours^*
	Rivaroxaban: 9
<15	Apixaban: 17^{^†}	No data	No data
	Edoxaban: 10 to 17^{^†}	Consider ≥48 hours^*	Consider ≥72 hours^*
	Rivaroxaban: 13^{^†}