Table 2A.

Recommended Durations for Interrupting Oral Direct Thrombin Inhibitor in the Preprocedural Setting: Dabigatran43,57,73

Creatinine Clearance (ml/min)Estimated Half-Life (hours)Duration of Interruption
Low PBRIntermediate/High/Uncertain PBR
≥8013≥24 hours≥48 hours
50 to 7915≥36 hours≥72 hours
30 to 4918≥48 hours>96
15 to 2927≥72 hours≥120 hours
<1530 (off dialysis)No data* Consider ≥96 hoursNo data
  • PBR, procedural bleeding risk.

  • * Consider measuring dilute thrombin time (dTT).