Table 2.

Overview of Common Fibrotic Lung Diseases

	Pulmonary	Radiology	Treatment
UIP	Older age	Subpleural	Anti fibrotic medications
	Male sex	Basilar predominant	Consider referral for lung transplant soon after diagnosis as course is unpredictable and inexorable
	Smoking history	Honeycombing	Anti-inflammatory and immunosuppressive Rx NOT indicated (may be harmful)
	Crackles at lung bases
	Clubbing
NSIP	Younger age	Homogeneous	Anti-inflammatory medications
	Female sex	Bronchovascular	Consider referral for lung transplant if advanced disease
	Connective tissue disease	Lower lobe	Consider referral for lung transplant if advanced disease
	Positive serologies	Dilated esophagus
		Peripheral sparring
CHP	Older age	Peribronchiolar fibrosis	Anti-inflammatory medications
	Female	Air trapping	Removal of causative antigen
	Bird owner	Upper lobe	Consider referral for lung transplant if advanced disease
	Mold exposure		Consider referral for lung transplant if advanced disease
S4	Younger age	Upper lobe posterior	Anti-inflammatory medications
	Less symptomatic	Calcified lymph nodes	Consider transplantation for advanced disease (PHN, hypoxemia, declining PFT's)
		Peribronchiolar fibrosis

CHP, chronic hypersensitivity pneumonitis; NSIP, non-specific interstitial pneumonitis; S4, stage 4 sarcoidosis; PFT, Pulmonary Function Test; PHN, pulmonary hypertension; UIP, usual interstitial pneumonitis.