RT Journal Article SR Electronic T1 The “New Genetics” in Clinical Practice: A Brief Primer JF The Journal of the American Board of Family Medicine JO J Am Board Fam Med FD American Board of Family Medicine SP 377 OP 379 DO 10.3122/jabfm.2017.03.160316 VO 30 IS 3 A1 Aubrey Milunsky YR 2017 UL http://www.jabfm.org/content/30/3/377.abstract AB Major advances in human genetics have led to the identification of 4451 genes to date with disease-carrying mutations, thereby enabling precise diagnoses of all of these monogenic disorders. Limitations to the use of the “new genetics” do exist, however, including the recognition of genetic heterogeneity, many variants of unknown significance, and incidental diagnoses. This article reviews information to help use these advances to aid accurate diagnoses, identify carriers, and determine prenatal diagnoses, providing opportunities to avoid or prevent serious and fatal genetic disorders.