<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kool, Marijke</style></author><author><style face="normal" font="default" size="100%">Elshout, Gijs</style></author><author><style face="normal" font="default" size="100%">Koes, Bart W.</style></author><author><style face="normal" font="default" size="100%">Bohnen, Arthur M.</style></author><author><style face="normal" font="default" size="100%">Berger, Marjolein Y.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">C-Reactive Protein Level as Diagnostic Marker in Young Febrile Children Presenting in a General Practice Out-of-Hours Service</style></title><secondary-title><style face="normal" font="default" size="100%">The Journal of the American Board of Family
                Medicine</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2016-07-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">460-468</style></pages><doi><style  face="normal" font="default" size="100%">10.3122/jabfm.2016.04.150315</style></doi><volume><style face="normal" font="default" size="100%">29</style></volume><issue><style face="normal" font="default" size="100%">4</style></issue><abstract><style  face="normal" font="default" size="100%">Background: It is unclear how well a C-reactive protein (CRP) value predicts a serious infection (SI) in young febrile children in general practice.Methods: This prospective cohort study with 1-week follow-up included children, aged 3 months to 6 years, presenting with fever to a general practitioner out-of-hours service. We evaluate whether CRP level has predictive value for diagnosing a child at risk for an SI either at presentation or during follow-up. The index test was CRP ≤20 mg/L (rule out an SI) and &gt;80 mg/L (rule in an SI). The reference standard was referral to a pediatric emergency department or diagnosis of an SI. The main outcome measure was CRP value.Results: CRP level was available for 440 children. To rule out an SI, CRP ≤20 mg/L did not change the probability of having no SI (87.5%). CRP &gt;80 mg/L increased the probability of having an SI from 11.4% (pretest probability) to 21.2% (posttest probability). In children without a diagnosis of SI at presentation, CRP could not predict an SI during follow-up (CRP &gt;80 mg/L: positive likelihood ratio, 2.1, 95% confidence interval, 1.3–3.5; CRP ≤20 mg/L: negative likelihood ratio, 0.9, 95% confidence interval, 0.7–1.2).Conclusions: In general practice CRP has little clinically relevant value in discriminating febrile children in need of medical care from those who are not.</style></abstract></record></records></xml>