PT - JOURNAL ARTICLE AU - Timothy S. Carey AU - Jacqueline R. Halladay AU - Katrina E. Donahue AU - Samuel Cykert TI - Practice-based Research Networks (PBRNs) in the Era of Integrated Delivery Systems AID - 10.3122/jabfm.2015.05.140353 DP - 2015 Sep 01 TA - The Journal of the American Board of Family Medicine PG - 658--662 VI - 28 IP - 5 4099 - http://www.jabfm.org/content/28/5/658.short 4100 - http://www.jabfm.org/content/28/5/658.full SO - J Am Board Fam Med2015 Sep 01; 28 AB - Practice-based research networks (PBRNs) have been in existence for several decades, and they provide one mechanism to conduct research outside of academic research centers. Two transformative changes to the practice environment pose significant challenges to the manner in which PBRNs have functioned in the past and require changes to their current activities. The widespread introduction of electronic health records and the organization of practices into often hospital-dominated integrated delivery systems change the manner in which medicine is practiced, administered, and financed. Research funders are committed to extending research into communities, although we have yet to learn how to conduct these activities efficiently. We describe a number of operational challenges to this transformation, and we also propose ways to address these challenges and improve the quality and efficiency through which research is conducted. PBRNs can ensure their relevance in the research environment by adapting to this new era.