TY - JOUR T1 - Sarcoidosis: Current Concepts And Case Reports JF - The Journal of the American Board of Family Practice JO - J Am Board Fam Med SP - 211 LP - 217 DO - 10.3122/jabfm.1.3.211 VL - 1 IS - 3 AU - Joseph S. Shapiro Y1 - 1988/07/01 UR - http://www.jabfm.org/content/1/3/211.abstract N2 - Sarcoidosis is a systemic granulomatous disease of unknown etiology associated with various immune alterations and biochemical changes. This article reports recent advances in the conceptualization of the immune dysfunction with emphasis on helper T-cell overactivity in the lungs. Because 90 percent of patients with sarcoidosis have intrathoracic disease, the mode of presentation, radiographic findings, clinical course, and treatment of pulmonary involvement are discussed. Case reports are used to demonstrate the typical course of the disease and generally favorable outcome of the vast majority of patients seen in the non-referral setting. A rare case of neurosarcoidosis with neuroendocrine features is presented. ER -