RT Journal Article SR Electronic T1 Sarcoidosis: Current Concepts And Case Reports JF The Journal of the American Board of Family Practice JO J Am Board Fam Med FD American Board of Family Medicine SP 211 OP 217 DO 10.3122/jabfm.1.3.211 VO 1 IS 3 A1 Shapiro, Joseph S. YR 1988 UL http://www.jabfm.org/content/1/3/211.abstract AB Sarcoidosis is a systemic granulomatous disease of unknown etiology associated with various immune alterations and biochemical changes. This article reports recent advances in the conceptualization of the immune dysfunction with emphasis on helper T-cell overactivity in the lungs. Because 90 percent of patients with sarcoidosis have intrathoracic disease, the mode of presentation, radiographic findings, clinical course, and treatment of pulmonary involvement are discussed. Case reports are used to demonstrate the typical course of the disease and generally favorable outcome of the vast majority of patients seen in the non-referral setting. A rare case of neurosarcoidosis with neuroendocrine features is presented.