RT Journal Article
SR Electronic
T1 Neonatal Hyperbilirubinemia Caused By Pyruvate Kinase Deficiency
JF The Journal of the American Board of Family
                Practice
JO J Am Board Fam Med
FD American Board of Family Medicine
SP 288
OP 290
DO 10.3122/jabfm.1.4.288
VO 1
IS 4
A1 Steven G. Hammer
A1 Richard B. Lewan
YR 1988
UL http://www.jabfm.org/content/1/4/288.abstract
AB We report an infant with neonatal hyperbilirubinemia due to pyruvate kinase deficiency. The initial approach involved rapid evaluation, phototherapy, and dose monitoring of serum bilirubin levels. Follow-up induded maintenance on folic acid, monitoring blood counts, and educating the parents about the course of pyruvate kinase deficiency, especially aplastic crisis. We suggest that the informed family practitioner can manage neonatal hyperbilirubinemia and pyruvate kinase deficiency with referrals at critical times to pediatric or surgical specialists. The practitioner must be able to recognize quickly the need for exchange transfusion for severe jaundice and for blood transfusions or splenectomy when significant anemia or aplastic crisis occurs.