RT Journal Article SR Electronic T1 Papanicolaou Smear Adequacy: The Cervical Cytobrush And Ayre Spatula Compared With The Extended-Tip Spatula JF The Journal of the American Board of Family Practice JO J Am Board Fam Med FD American Board of Family Medicine SP 156 OP 160 DO 10.3122/jabfm.2.3.156 VO 2 IS 3 A1 Noel, Michael L. YR 1989 UL http://www.jabfm.org/content/2/3/156.abstract AB Papanicolaou smears have false-negative rates of 6 percent to 56 percent that are due, in large part, to inadequate sampling of endocervical cells. A randomized, prospective trial was conducted comparing the adequacy of Papanicolaou smears obtained with the cytobrush and Ayre spatula with smears obtained with the extended-tip spatula, as measured by the presence of endocervical cells. One hundred of 111 Papanicolaou smears obtained with a cytobrush and Ayre spatula contained endocervical cells (90.1 percent), compared with 68 of 105 smears obtained with the extended-tip spatula (64.8 percent) (χ2 = 18.6, P < 0.0001). There were no other significant differences between the two study groups for age, gravidity, parity, and hormone usage. The combination of the cytobrush and Ayre spatula appears to be superior to other methods that are currently used to obtain Papanicolaou smears.